I’m a biomedical anthropologist/epidemiologist with a post-doctoral studies in Human Genetics. I learned about pharmacology and medicinal chemistry at a large Swiss pharmaceutical company. There, we developed some of the first precision medicines in oncology—treating tumors with a specific protein signature. We took the next step to personalize prescription medicine, which is in its infancy. The goal is to prescribe the right drug, the first time—prescribing drugs that work with patient genes. As VP, Global Research Strategy and SVP, Global Pharmaceutical Strategy, this has been my vision for decades, and why I wrote The Goldilocks Genome to introduce personalized medicine to the lay public in a compelling read.
When San Francisco–based FDA epidemiologist Dr. Carrie Hediger’s best friend unexpectedly and conveniently dies, Carrie is determined to discover why and how she died. In her quest, she learns about the Golidlocks effect in 80 percent of prescription drugs: “too little” for 30 percent of patients; “too much” for 30 percent; and “just right” for the remaining 40 percent.
Grounded in science, pharmacology, data analysis, and current psychiatric practice, The Goldilocks Genome is simultaneously a taut, race-against-time thriller and a condemnation of psychiatry’s “One Size Fits All” approach to antidepressant prescriptions.
My mother was a Freudian psychiatrist who prescribed antidepressants as a last resort, while my brother, also a psychiatrist, turns to antidepressants as first-line therapy. I wanted to learn more about why my family members took these different approaches.
Before Prozac is a wonderful history and behind-the-scenes look at the medical treatment of depression and related disorders. I learned about the politics behind restricting access to benzodiazepines (like Valium®), how Prozac® was designed to be an anti-histamine until Lilly found a better indication and much more.
This is the first book I recommend to my friends who have a personal or academic interest in depression. I couldn’t put it down and suggest it to friends who are interested in the history of modern medicine.
Like most people, the two diseases of aging that scare me the most are ischemic stroke and Alzheimer’s disease. I don’t want to lose my ability to think, and I want to preserve my memory. So...there is no time like the present to explore what I can do to learn how to prevent Alzheimer’s disease.
Bredesen is the first neuroscientist I’ve encountered who describes different types of Alzheimer’s and offers practical diagnostic and dietary advice. I’ve explored his recommendations, and I think they’re sound. I’ve suggested this to many of my friends for them and/or for their parents and loved ones.
The instant New York Times and Wall Street Journal bestseller
A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline.
Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease.
In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing"…
Paganini was an extraordinary violinist because of his exceptionally flexible thumb. Why was his thumb so “bendy”? Genetics. His genes provided an opportunity, and he learned how to exploit it.
Each of us is genetically unique. Our challenge is to understand our genes, which can be positive or negative. The Violinist’s Thumb is a nice introduction to the importance of DNA and the impact of genes in history. Inbreeding in the European royals led to hemophilia and ultimately contributed to the fall of the Czar and the Russian Empire. Genes have played a major role in history, art, and science.
From New York Times bestselling author Sam Kean comes incredible stories of science, history, language, and music, as told by our own DNA.
In The Disappearing Spoon, bestselling author Sam Kean unlocked the mysteries of the periodic table. In The Violinist's Thumb, he explores the wonders of the magical building block of life: DNA.
There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more…
There is nothing that worries me more than when I hear that someone has been transferred to the intensive care unit with an infectious disease.
There are reasonable, not perfect, treatments and approaches to treat bacterial infections—although they are becoming fewer and fewer. Rarely discussed is the threat of fungal infection with Candida auris in hospitals—a treatment-resistant and hearty strain that is infecting and taking the lives of immunocompromised or weakened patients in the hospital. Unlike bacteria and viruses, fungi are resilient and can remain dormant in many environments. It is not just hospitals where fungi are dangerous; they can infect the lungs of desert dwellers and cause destruction in forests.
I suggest this book to my friends who want to be aware and take precautions (as much as possible) and encourage pharma and biotech to develop new tools/medicines to control deadly hospital infections.
Fungi are everywhere. Most are harmless, some are helpful. A few are killers. Collectively, infectious fungi are the most devastating agents of disease on Earth, and a fungus that can persist in the environment without its host is here for the long haul. In gripping, accessible prose, Emily Monosson documents how changing climate, trade and travel are making us all more vulnerable to invasion. Populations of bats, frogs and salamanders face extinction, and scientists don't have a cure. The American Northwest's beloved National Parks are covered with the spindly corpses of white bark pines. Food crops are under siege, threatening…
Who doesn’t love a true story of David and Goliath? Who really believes that the inventor of the “better mousetrap” always wins? This is a real-life medical thriller when the properties of a mineral were found to be a cheaper, better solution to stopping battlefield bleeding.
The “Davids” took on “Goliath,” who supported their vested interests in an inferior product that cost the lives of infantrymen. It took a courageous whistle-blower to come forward and change the trajectory. Ultimately the mineral was adopted and used effectively in the Iraq War. The better trauma medicine won, but it took years. The story is, sadly, all too real—but good does triumph!
The "high-stakes" true story of how an absent-minded inventor and a down-on-his-luck salesman joined forces to create a once‑in‑a‑generation lifesaving product: "Suspenseful storytelling helps us see and feel the struggle and frustration, the sweat and tears . . . Inspiring” (Robert Kolker, #1 New York Times bestselling author of Hidden Valley Road).
At the 1993 Battle of Mogadishu, dramatized by the popular film Black Hawk Down, the majority of soldiers who died were killed instantly or bled to death before they could reach an operating table. This tragedy reinforced the need for a revolutionary treatment that could transform trauma medicine.…
Reading was a childhood passion of mine. My mother was a librarian and got me interested in reading early in life. When John F. Kennedy was running for president and after his assassination, I became intensely interested in politics. In addition to reading history and political biographies, I consumed newspapers and television news. It is this background that I have drawn upon over the decades that has added value to my research.
It didn’t begin with Donald Trump. When the Republican Party lost five straight presidential elections during the 1930s and 1940s, three things happened: (1) Republicans came to believe that presidential elections are rigged; (2) Conspiracy theories arose and were believed; and (3) The presidency was elevated to cult-like status.
Long before Trump, each of these phenomena grew in importance. The John Birch Society and McCarthyism became powerful forces; Dwight D. Eisenhower was the first “personal president” to rise above the party; and the development of what Harry Truman called “the big lie,” where outrageous falsehoods came to be believed. Trump…
Grand Old Unraveling: The Republican Party, Donald Trump, and the Rise of Authoritarianism
It didn't begin with Donald Trump. The unraveling of the Grand Old Party has been decades in the making. Since the time of FDR, the Republican Party has been home to conspiracy thinking, including a belief that lost elections were rigged. And when Republicans later won the White House, the party elevated their presidents to heroic status-a predisposition that eventually posed a threat to democracy. Building on his esteemed 2016 book, What Happened to the Republican Party?, John Kenneth White proposes to explain why this happened-not just the election of Trump but the authoritarian shift in the party as a…
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